[PDF][PDF] The analgesic effects of celecoxib on the formalin-induced short-and long-term inflammatory pain
YQ Zhao, W Hai-Yan, Y Jun-Bin, Y Sun… - Pain …, 2017 - painphysicianjournal.com
The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in
spite of moderate gastrointestinal side effects. In previous studies, it has been shown that …
spite of moderate gastrointestinal side effects. In previous studies, it has been shown that …
Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats
APC Veiga, IDG Duarte, MN Ávila, PG da Motta… - Life sciences, 2004 - Elsevier
Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …
leads to an increase in the excitability of neurons present in dorsal horn. This increased …
Crucial involvement of actin filaments in celecoxib and morphine analgesia in a model of inflammatory pain
P Paiva-Lima, RM Rezende, R Leite… - Journal of Pain …, 2012 - Taylor & Francis
Background Celecoxib exerted analgesic effects (hypoalgesia) reversed by opioid receptor
antagonists in a model of inflammatory pain. To analyze this celecoxib-induced hypoalgesia …
antagonists in a model of inflammatory pain. To analyze this celecoxib-induced hypoalgesia …
Analgesic effects of intrathecally administered celecoxib, a cyclooxygenase‐2 inhibitor, in the tail flick test and the formalin test in rats
T Nishiyama - Acta anaesthesiologica scandinavica, 2006 - Wiley Online Library
Background: The analgesic effects of celecoxib, a cyclooxygenase‐2 (COX‐2) inhibitor, on
formalin‐induced pain are still controversial. The purpose of this study was to examine the …
formalin‐induced pain are still controversial. The purpose of this study was to examine the …
Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test
The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the
formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) …
formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) …
Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats
RM Rezende, P Paiva-Lima, WGP Dos Reis… - …, 2010 - Elsevier
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …
[HTML][HTML] Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
BCA Gassani, RM Rezende, P Paiva-Lima… - Pharmacological …, 2010 - Elsevier
In a model of peripherally induced inflammatory pain in rats, selective inhibitors of
cyclooxygenase (COX)-2 raised nociceptive thresholds above basal values, an effect …
cyclooxygenase (COX)-2 raised nociceptive thresholds above basal values, an effect …
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids
RM Rezende, WGP Dos Reis, IDG Duarte, PP Lima… - Pain, 2009 - journals.lww.com
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …
Celecoxib reduces hyperalgesia and tactile allodynia in diabetic rats
IE Juárez-Rojop, PE Morales-Hernández… - Pharmacological …, 2015 - Elsevier
Background In the present study we determined the antihyperalgesic and antiallodynic effect
of celecoxib in diabetic rats as well as the possible participation of opioid receptors in the …
of celecoxib in diabetic rats as well as the possible participation of opioid receptors in the …
The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
W Koppert, A Wehrfritz, N Körber, R Sittl, S Albrecht… - Pain, 2004 - journals.lww.com
Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …