Anti‐IFN‐α/‐ω neutralizing antibodies from COVID‐19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity
F Frasca, M Scordio, L Santinelli… - European journal of …, 2022 - Wiley Online Library
A significant number of COVID‐19 patients were shown to have neutralizing antibodies
(NAB) against IFN; however, NAB specificity, fluctuation over time, associations with …
(NAB) against IFN; however, NAB specificity, fluctuation over time, associations with …
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients
D Goncalves, M Mezidi, P Bastard… - Clinical & …, 2021 - Wiley Online Library
Objectives Impairment of type I interferon (IFN‐I) immunity has been reported in critically ill
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
[HTML][HTML] Neutralizing type I interferon autoantibodies in Japanese patients with severe COVID-19
S Eto, Y Nukui, M Tsumura, Y Nakagama… - Journal of Clinical …, 2022 - Springer
Purpose Autoantibodies (aAbs) to type I interferons (IFNs) have been found in less than 1%
of individuals under the age of 60 in the general population, with the prevalence increasing …
of individuals under the age of 60 in the general population, with the prevalence increasing …
[HTML][HTML] Early and rapid identification of COVID-19 patients with neutralizing type I interferon auto-antibodies
B Akbil, T Meyer, P Stubbemann, C Thibeault… - Journal of clinical …, 2022 - Springer
Purpose Six to 19% of critically ill COVID-19 patients display circulating auto-antibodies
against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for …
against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for …
[HTML][HTML] Neutralizing autoantibodies to type I IFNs in> 10% of patients with severe COVID-19 pneumonia hospitalized in Madrid, Spain
J Troya, P Bastard, L Planas-Serra, P Ryan… - Journal of clinical …, 2021 - Springer
Background In a recent study, autoantibodies neutralizing type I interferons (IFNs) were
present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies …
present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies …
[HTML][HTML] Transient increase of pre-existing anti-IFN-α2 antibodies induced by SARS-CoV-2 infection
S Steels, J Van Elslande… - Journal of Clinical …, 2022 - Springer
To the Editor, Bastard et al. reported that autoantibodies neutralizing type I interferons (IFN)
s are found in at least 18% of deceased COVID-19 patients [1]. They also showed that the …
s are found in at least 18% of deceased COVID-19 patients [1]. They also showed that the …
[HTML][HTML] Interferon-α2 auto-antibodies in convalescent plasma therapy for COVID-19
MP Raadsen, A Gharbharan, CCE Jordans… - Journal of clinical …, 2022 - Springer
Purpose To study the effect of interferon-α2 auto-antibodies (IFN-α2 Abs) on clinical and
virological outcomes in critically ill COVID-19 patients and the risk of IFN-α2 Abs transfer …
virological outcomes in critically ill COVID-19 patients and the risk of IFN-α2 Abs transfer …
[HTML][HTML] The detectable anti-interferon-γ autoantibodies in COVID-19 patients may be associated with disease severity
PK Chen, KJ Yeo, SH Chang, TL Liao, CH Chou… - Virology Journal, 2023 - Springer
Background Neutralizing anti-interferon (IFN)-γ autoantibodies are linked to adult-onset
immunodeficiency and opportunistic infections. Methods To explore whether anti-IFN-γ …
immunodeficiency and opportunistic infections. Methods To explore whether anti-IFN-γ …
Autoantibodies neutralizing type III interferons are uncommon in patients with severe coronavirus disease 2019 pneumonia
M Vanker, K Särekannu, A Fekkar… - Journal of Interferon & …, 2023 - liebertpub.com
Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain… - Science …, 2021 - science.org
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1: 10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID …
diluted 1: 10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID …