The actin cytoskeleton and actin-based motility

T Svitkina - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

Biochemical and mechanical regulation of actin dynamics

P Lappalainen, T Kotila, A Jégou… - … Reviews Molecular Cell …, 2022 - nature.com
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Ultrastructure of the actin cytoskeleton

TM Svitkina - Current opinion in cell biology, 2018 - Elsevier
The actin cytoskeleton is the primary force-generating machinery in the cell, which can
produce pushing (protrusive) forces using energy of actin polymerization and pulling …

Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

The actin cytoskeleton in normal and pathological cell motility

A Lambrechts, M Van Troys, C Ampe - … journal of biochemistry & cell biology, 2004 - Elsevier
Cell motility is crucial for tissue formation and for development of organisms. Later on cell
migration remains essential throughout the lifetime of the organism for wound healing and …

Actin assembly mechanisms at a glance

K Rottner, J Faix, S Bogdan, S Linder… - Journal of cell …, 2017 - journals.biologists.com
The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Actin and microtubules in cell motility: which one is in control?

S Etienne‐Manneville - Traffic, 2004 - Wiley Online Library
The cytoskeleton is composed of three distinct elements: actin microfilaments, microtubules
and intermediate filaments. The actin cytoskeleton is thought to provide protrusive and …

Signaling to actin dynamics

LM Machesky, RH Insall - The Journal of cell biology, 1999 - rupress.org
THE actin cytoskeleton of a eukaryotic cell is central to locomotion, phagocytosis,
contractility, shape changes, cytokinesis and maintenance of polarity. The mechanisms …

[HTML][HTML] Actin filaments as tension sensors

VE Galkin, A Orlova, EH Egelman - Current Biology, 2012 - cell.com
The field of mechanobiology has witnessed an explosive growth over the past several years
as interest has greatly increased in understanding how mechanical forces are transduced by …

Actin mechanics and fragmentation

M Enrique, ML Gardel - Journal of Biological Chemistry, 2015 - ASBMB
Cell physiological processes require the regulation and coordination of both mechanical
and dynamical properties of the actin cytoskeleton. Here we review recent advances in …