Although long-term potentiation (LTP) has been studied as the mechanism for hippocampus-
dependent learning and memory, evidence for this hypothesis is still incomplete. The mice …

As a first step in a program to use genetically altered mice in the study of memory
mechanisms, mutant mice were produced that do not express the α-calcium-calmodulin …

The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-
term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM) …

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism
for the establishment of certain forms of explicit memory in the mammalian brain. As is the …

What are the long-lasting changes that occur in your brain as you learn new information? It
is generally thought that memory is due to persistent modification of the strength of …

Calcium-calmodulin-dependent protein kinase II (CaMKII) is a necessary component of the
cellular machinery underlying learning and memory. Here, a constitutively active form of this …

Cortical plasticity seems to be critical for the establishment of permanent memory traces,,.
Little is known, however, about the molecular and cellular processes that support …

Analogous to learning and memory storage, long-term potentiation (LTP) is divided into
induction and maintenance phases. Testing the hypothesis that the mechanism of LTP …

Brief repetitive activation of excitatory synapses in the hippocampus leads to an increase in
synaptic strength that lasts for many hours. This long-term potentiation (LTP) of synaptic …

The effectiveness of long-term potentiation (LTP) as a mechanism for information storage
would be severely limited if processes that decrease synaptic strength did not also exist. In …