Misuse of opioids can lead to a potential lethal overdose. Timely administration of naloxone
is critical for survival. Here, we designed a polymer–naloxone conjugate that can provide on …

The mu opioid receptor antagonist naloxone has been a vital, long-standing
countermeasure in the ongoing battle against opioid use disorders (OUD) and toxicity …

Chronic use of opioids can lead to tolerance, dependence, abuse, and addiction. This in turn
can result in dose escalation and opioid overdose. Opioid overdose can be fatal due to …

The opioid epidemic currently plaguing the United States has been exacerbated by an
alarming rise in fatal overdoses as a result of the proliferated abuse of synthetic mu opioid …

Background and Purpose Opioid‐based drugs are the gold standard medicines for pain
relief. However, tolerance and several side effects (ie constipation and dependence) may …

Thousands of individuals die each year from opioid‐related overdoses. While naloxone
(Narcan®) is currently the most widely employed treatment to reverse opioid toxicity, high or …

Opioids are commonly prescribed to address intense, ongoing pain associated with cancer,
as well as long-lasting noncancer-related pain when alternative methods have proven …

We report a phototriggerable formulation enabling in vivo repeated and on-demand
anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) …

The spatiotemporal dynamics of opioid signaling in the brain remain poorly defined.
Photoactivatable opioid ligands provide a means to quantitatively measure these dynamics …

Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult
to interface with recordings of neural activity. Here, we demonstrate the feasibility and …