Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

Oral cancer pain is attributed to the release from cancers of mediators that sensitize and
activate sensory neurons. Intraplantar injection of conditioned media (CM) from human …

Background Cancer pain severely limits function and significantly reduces quality of life.
Subtypes of sensory neurons involved in cancer pain and proliferation are not clear …

The incidence of pain in cancer patients during diagnosis and treatment is exceedingly high.
Although advances in cancer detection and therapy have improved patient prognosis …

Solid tumors are complex collections of cells surrounded by benign tissues that influence
and are influenced by the tumor. These surrounding cells include vasculature, immune cells …

Cancer pain is an ever-present public health concern. With innovations in treatment, cancer
patients are surviving longer, but uncontrollable pain creates a poor quality of life for these …

Background Pain in the head neck area is an early symptom in oral cancer, supporting the
hypothesis that cancer cells control the activities of surrounding nociceptors at the site of the …

The role of the nervous system in aiding cancer progression and metastasis is an important
aspect of cancer pathogenesis. Interaction between cancer cells and neurons in an in vitro …

Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a
mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and …

Pain is the most disruptive influence on the quality of life of cancer patients. Although
significant advances are being made in cancer treatment and diagnosis, the basic …