Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Circadian rhythm disorders constitute a group of phenotypes that usually present as altered
sleep–wake schedules. Until a human genetics approach was applied to investigate these …

Nearly all living organisms, from cyanobacteria to humans, have an internal circadian
oscillation with a periodicity of approximately 24 h. In mammals, circadian rhythms regulate …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Sleep is regulated by two broad mechanisms: the circadian system, which generates 24-h
rhythms of sleep propensity and a wake-dependent homeostatic sleep process whereby …

Circadian cycles affect a variety of physiological processes, and disruptions of normal
circadian biology therefore have the potential to influence a range of disease-related …

The sleep-wake cycle displays a characteristic 24-hour periodicity, providing an opportunity
to dissect the endogenous circadian clock through the study of aberrant behaviour. This …

Almost all organisms organize their physiology, behavior, and metabolism according to the
24-hour solar cycle. Time-dependent changes in these parameters have evolved to allow …

Abstract Study Objectives: Chronotype, or diurnal preference, refers to behavioral
manifestations of the endogenous circadian system that governs preferred timing of sleep …