Hypospadias results from the impaired urethral development, which is influenced by
androgens, but its genetic etiology is still unknown. Through whole exome sequencing …

Background Hypospadias is a common congenital malformation of male external genitalia,
which mainly manifests as an abnormal urethral opening on the ventral side of the penis …

Background Next-generation sequencing (NGS) is generally used for patients with severe
disorders of sex development (DSD). However, NGS has not been applied extensively for …

Hypospadias is a common male genital malformation and is regarded as a complex disease
affected by multiple genetic as well as environmental factors. In a previous genome-wide …

Hypospadias is a common congenital condition in boys in which the urethra opens on the
underside of the penis. We performed a genome-wide association study on 1,006 surgery …

STUDY QUESTION What percentage of cases with non-syndromic hypospadias can be
ascribed to mutations in known causative/candidate/susceptibility genes or submicroscopic …

Background Hypospadias risk–associated gene variants have been reported in populations
of European descent using genome-wide association studies (GWASs). There is little known …

It is estimated that around 10–20% of hypospadias are caused by genetic abnormalities
worldwide although the spectrum of associated genes does vary across different ethnicities …

Background The genetic association of hypospadias-risk studies has been conducted in
Caucasians, Chinese-Han populations and few in Indian populations. However, no …

This review evaluates current knowledge related to trends in the prevalence of hypospadias,
the association of hypospadias with endocrine‐disrupting exposures, and the potential …