Injectable pH thermo-responsive hydrogel scaffold for tumoricidal neural stem cell therapy for glioblastoma multiforme

JL King, P Maturavongsadit, SD Hingtgen… - Pharmaceutics, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and
despite recent advances in treatment modalities, GBM remains incurable. Injectable …

Thermosensitive composite hydrogel incorporated with curcumin-loaded nanopolymersomes for prolonged and localized treatment of glioma

M Babaei, J Davoodi, R Dehghan, M Zahiri… - Journal of Drug Delivery …, 2020 - Elsevier
In the current study, in order to augment the therapeutic efficacy of curcumin, thermo-
sensitive biodegradable hydrogel composed of poly (ε-caprolactone-co-lactide)-b-poly …

Three‐dimensional biomimetic hyaluronic acid hydrogels to investigate glioblastoma stem cell behaviors

PS Nakod, Y Kim, SS Rao - Biotechnology and Bioengineering, 2020 - Wiley Online Library
Glioblastoma multiforme (GBM) is the deadliest form of primary brain tumor. GBM tumors are
highly heterogeneous, being composed of tumor cells as well as glioblastoma stem cells …

Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells

E Bozzato, N Tsakiris, A Paquot, GG Muccioli… - International journal of …, 2022 - Elsevier
Glioblastoma (GBM) recurrences are inevitable, and mainly originate from residual tumor
cells and the presence of glioma stem cells (GSC) around the resection cavity borders. We …

Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem‐Like Cells with CXCL12‐Mediated Chemotaxis

ZM Khan, JM Munson, TE Long… - Advanced …, 2023 - Wiley Online Library
Glioblastoma (GBM), characterized by high infiltrative capacity, is the most common and
deadly type of primary brain tumor in adults. GBM cells, including therapy‐resistant …

Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma

G Brachi, J Ruiz-Ramirez, P Dogra, Z Wang, V Cristini… - Nanoscale, 2020 - pubs.rsc.org
Intratumoral drug delivery is a promising approach for the treatment of glioblastoma
multiforme (GBM). However, drug washout remains a major challenge in GBM therapy. Our …

Characterization and structure-property relationships of an injectable thiol-Michael addition hydrogel toward compatibility with glioblastoma therapy

ZM Khan, E Wilts, E Vlaisavljevich, TE Long… - Acta Biomaterialia, 2022 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive primary brain cancer and although patients
undergo surgery and chemoradiotherapy, residual cancer cells still migrate to healthy brain …

Glioblastoma spheroid growth and chemotherapeutic responses in single and dual-stiffness hydrogels

J Bruns, T Egan, P Mercier, SP Zustiak - Acta Biomaterialia, 2023 - Elsevier
Glioblastoma (GBM) is the deadliest brain tumor for which there is no cure. Bioengineered
GBM models, such as hydrogel-encapsulated spheroids, that capture both cell-cell and cell …

Polymeric biomaterial scaffolds for tumoricidal stem cell glioblastoma therapy

KM Moore, AB Murthy, EG Graham-Gurysh… - ACS biomaterials …, 2020 - ACS Publications
Glioblastoma (GBM) is the most common primary brain tumor and has a poor prognosis; as
such, there is an urgent need to develop innovative new therapies. Tumoricidal stem cells …

Nano composite thermo-sensitive gel for paclitaxel and temozolomide co-delivery to glioblastoma cells

Y Xu, M Shen, Y Sun, P Gao… - Journal of Nanoscience …, 2016 - ingentaconnect.com
In this work, we have reported the preparation and optimization of paclitaxel (PTX) and
temozolomide (TMZ) loaded monomethoxy (polyethylene glycol)-poly (D, L-lactide-co …