Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-
term administration, expensive drugs associated with severe side effects. Considering these …

Among neglected tropical diseases, leishmaniasis is one of the leading causes, not only of
deaths but also of disability-adjusted life years. This disease, caused by protozoan parasites …

Natural metabolites present an extraordinary chemo-diversity and have been used as the
inspiration for new drugs. Considering the need for new treatments against the neglected …

The available therapeutic treatment for leishmaniasis is inadequate and toxic due to side
effects, expensive and emergence of drug resistance. Affordable and safe antileishmanial …

This work describes the design, synthesis, and biological activities of new selenoester
derivatives and its homologs thioesters. Thirty-two compounds were developed following an …

Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line
drugs, but this therapy has shown severe adverse effects. An alternative to minimize this …

Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and
includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine) …

Leishmaniasis and Chagas disease are parasitic protozoan infections that affect the poorest
population in the world, causing high mortality and morbidity. As a result of highly toxic and …

Leishmania braziliensis is one of the pathogenic agents of cutaneous and mucocutanoeous
leishmaniasis. There are no validated vaccines to prevent the infection and the treatment …

Visceral leishmaniasis (VL) is a life threatening infectious disease caused by Leishmania
donovani. It leads to the severe immune suppression in the host defense system. Higher …