[HTML][HTML] Cognitive control deficits in schizophrenia: mechanisms and meaning

TA Lesh, TA Niendam, MJ Minzenberg… - …, 2011 - nature.com
Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem

D Dickinson, PD Harvey - Schizophrenia bulletin, 2009 - academic.oup.com
The schizophrenia research community, including government, industry, and academia, has
made development of procognitive treatment strategies a priority. Much current research is …

Cognition in schizophrenia: core psychological and neural mechanisms

DM Barch, A Ceaser - Trends in cognitive sciences, 2012 - cell.com
The challenge in understanding cognitive impairment in schizophrenia is that people with
this illness have deficits in an array of domains. Here, we briefly review evidence regarding …

[HTML][HTML] Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia

TA Lesh, AJ Westphal, TA Niendam, JH Yoon… - NeuroImage: Clinical, 2013 - Elsevier
Cognitive control deficits have been consistently documented in patients with schizophrenia.
Recent work in cognitive neuroscience has hypothesized a distinction between two …

[HTML][HTML] Executive function, neural circuitry, and genetic mechanisms in schizophrenia

DP Eisenberg, KF Berman - Neuropsychopharmacology, 2010 - nature.com
After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …

[HTML][HTML] Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Cognitive deficits and functional outcome in schizophrenia

CR Bowie, PD Harvey - Neuropsychiatric disease and treatment, 2006 - Taylor & Francis
Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe
across several domains, including attention, working memory, verbal learning and memory …

Neural correlates of cognitive deficits across developmental phases of schizophrenia

S Kelly, S Guimond, A Lyall, WS Stone… - Neurobiology of …, 2019 - Elsevier
Schizophrenia is associated with cognitive deficits across all stages of the illness (ie, high
risk, first episode, early and chronic phases). Identifying the underlying neurobiological …

Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral …

JH Yoon, MJ Minzenberg, S Ursu… - American Journal of …, 2008 - Am Psychiatric Assoc
Objective: Although deficits in cognitive control are thought to contribute to the diverse
cognitive and behavioral abnormalities in individuals with schizophrenia, the neural …

Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications

MF Green, DL Braff - Biological psychiatry, 2001 - Elsevier
Neurocognitive deficits have become increasingly important defining features of
schizophrenia and its treatment. Multiple domains of neurocognitive functions are impaired …