The first gene therapy clinical trials were initiated more than two decades ago. In the early
days, gene therapy shared the fate of many experimental medicine approaches and was …

In Part I of this Review, we introduced recent advances in gene delivery technologies and
explained how they have powered some of the current human gene therapy applications. In …

Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Gene therapy is the treatment of a disease through transferring genetic material into cells of
the patients. In the recent several years, gene therapy has experienced rapid progress and …

Abstract Currently, 33 gene‐therapy drugs/products have been approved in the clinic. Over
3000 completed and ongoing clinical gene therapy trials have been reported worldwide …

Gene therapies are gaining momentum as promising early successes in clinical studies
accumulate and examples of regulatory approval for licensing increase. Investigators are …

Therapeutic gene transfer holds the promise of providing lasting therapies and even cures
for diseases that were previously untreatable or for which only temporary or suboptimal …

The field of gene therapy is striving more than ever to define a path to the clinic and the
market. Twenty gene therapy products have already been approved and over two thousand …

The concept of gene therapy was envisioned soon after the emergence of restriction
endonucleases and subcloning of mammalian genes in phage and plasmids. Over the …

Improvements in the gene transfer vectors used in therapeutic trials have led to substantial
clinical successes in patients with serious genetic conditions, such as immunodeficiency …