The Oxytocin Puzzle: Unlocking Alzheimer's Disease
MC Selles, MM Oliveira - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Alzheimer's disease is a multi-factorial disease that disrupts many aspects of human
behavior. In this comment, we highlight the work by Koulousakis et al. published in a recent …
behavior. In this comment, we highlight the work by Koulousakis et al. published in a recent …
Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory …
J Takahashi, Y Ueta, D Yamada… - …, 2022 - Wiley Online Library
Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid
peptide (25–35)(Aβ25–35)‐induced impairments of the murine hippocampal synaptic …
peptide (25–35)(Aβ25–35)‐induced impairments of the murine hippocampal synaptic …
Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice
MC Selles, JTS Fortuna, YPR de Faria, LD Siqueira… - Iscience, 2023 - cell.com
Alzheimer's disease (AD) is characterized by neurodegeneration, memory loss, and social
withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We …
withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We …
Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice
J Takahashi, D Yamada, Y Ueta, T Iwai, E Koga… - Biochemical and …, 2020 - Elsevier
Aim Oxytocin, a peptide hormone synthesized in the hypothalamic paraventricular nucleus,
has been reported to participate in the regulation of learning and memory performance …
has been reported to participate in the regulation of learning and memory performance …
[HTML][HTML] Oxytocin's dynamic role across the lifespan
K Audunsdottir, DS Quintana - Aging Brain, 2022 - Elsevier
Older adults have been neglected in biobehavioral oxytocin research. Emerging research
indicates that oxytocin signaling activity fluctuates over the lifespan, which suggests that …
indicates that oxytocin signaling activity fluctuates over the lifespan, which suggests that …
Exogenous oxytocin administration restores memory in female APP/PS1 mice
P Koulousakis, E Willems, M Schepers… - Journal of …, 2023 - content.iospress.com
Background: Current treatment options for Alzheimer's disease (AD) are limited, inefficient,
and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of …
and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of …
From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders
A Romano, B Tempesta… - Frontiers in …, 2016 - frontiersin.org
Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and
supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a …
supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a …
Potential role of oxytocin in the regulation of memories and treatment of memory disorders
Oxytocin (OXT) is an “affiliative” hormone or neurohormone or neuropeptide consists of nine
amino acids, synthesized in magnocellular neurons of paraventricular (PVN) and supraoptic …
amino acids, synthesized in magnocellular neurons of paraventricular (PVN) and supraoptic …
Plasma oxytocin is not associated with social cognition or behavior in frontotemporal dementia and Alzheimer's disease syndromes
EG Johnson, W Kuiper, RM Ahmed… - Dementia and Geriatric …, 2022 - karger.com
Introduction: Changes in social behavior and emotion processing are common in
frontotemporal dementia (FTD) and semantic dementia (SD), and less so in Alzheimer's …
frontotemporal dementia (FTD) and semantic dementia (SD), and less so in Alzheimer's …
[HTML][HTML] Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors
Although intranasal oxytocin administration to tap into central functions is the most
commonly used non-invasive means for exploring oxytocin's role in human cognition and …
commonly used non-invasive means for exploring oxytocin's role in human cognition and …