The Oxytocin Puzzle: Unlocking Alzheimer's Disease

MC Selles, MM Oliveira - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Alzheimer's disease is a multi-factorial disease that disrupts many aspects of human
behavior. In this comment, we highlight the work by Koulousakis et al. published in a recent …

Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory …

J Takahashi, Y Ueta, D Yamada… - …, 2022 - Wiley Online Library
Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid
peptide (25–35)(Aβ25–35)‐induced impairments of the murine hippocampal synaptic …

Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

MC Selles, JTS Fortuna, YPR de Faria, LD Siqueira… - Iscience, 2023 - cell.com
Alzheimer's disease (AD) is characterized by neurodegeneration, memory loss, and social
withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We …

Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice

J Takahashi, D Yamada, Y Ueta, T Iwai, E Koga… - Biochemical and …, 2020 - Elsevier
Aim Oxytocin, a peptide hormone synthesized in the hypothalamic paraventricular nucleus,
has been reported to participate in the regulation of learning and memory performance …

[HTML][HTML] Oxytocin's dynamic role across the lifespan

K Audunsdottir, DS Quintana - Aging Brain, 2022 - Elsevier
Older adults have been neglected in biobehavioral oxytocin research. Emerging research
indicates that oxytocin signaling activity fluctuates over the lifespan, which suggests that …

Exogenous oxytocin administration restores memory in female APP/PS1 mice

P Koulousakis, E Willems, M Schepers… - Journal of …, 2023 - content.iospress.com
Background: Current treatment options for Alzheimer's disease (AD) are limited, inefficient,
and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of …

From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders

A Romano, B Tempesta… - Frontiers in …, 2016 - frontiersin.org
Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and
supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a …

Potential role of oxytocin in the regulation of memories and treatment of memory disorders

V Walia, P Wal, S Mishra, A Agrawal, S Kosey, AD Patil - Peptides, 2024 - Elsevier
Oxytocin (OXT) is an “affiliative” hormone or neurohormone or neuropeptide consists of nine
amino acids, synthesized in magnocellular neurons of paraventricular (PVN) and supraoptic …

Plasma oxytocin is not associated with social cognition or behavior in frontotemporal dementia and Alzheimer's disease syndromes

EG Johnson, W Kuiper, RM Ahmed… - Dementia and Geriatric …, 2022 - karger.com
Introduction: Changes in social behavior and emotion processing are common in
frontotemporal dementia (FTD) and semantic dementia (SD), and less so in Alzheimer's …

[HTML][HTML] Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors

S Xiao, NC Ebner, A Manzouri, TQ Li, DS Cortes… - …, 2024 - Elsevier
Although intranasal oxytocin administration to tap into central functions is the most
commonly used non-invasive means for exploring oxytocin's role in human cognition and …