Vascular mechanobiology endothelial cell responses to fluid shear stress

J Ando, K Yamamoto - Circulation Journal, 2009 - jstage.jst.go.jp
Endothelial cells (ECs) lining blood vessel walls respond to shear stress, a fluid mechanical
force generated by flowing blood, and the EC responses play an important role in the …

The shear stress of it all: the cell membrane and mechanochemical transduction

CR White, JA Frangos - … of the Royal Society B: Biological …, 2007 - royalsocietypublishing.org
As the inner lining of the vessel wall, vascular endothelial cells are poised to act as a signal
transduction interface between haemodynamic forces and the underlying vascular smooth …

Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress

M Takahashi, T Ishida, O Traub, MA Corson… - Journal of vascular …, 1997 - karger.com
Fluid shear stress is one of the most important mechanical forces acting upon vascular
endothelium, because of its location at the interface between the bloodstream and vascular …

Overview: temporal and spatial relationships in shear stress-mediated endothelial signalling

PF Davies - Journal of vascular research, 1997 - search.proquest.com
Arteries possess a remarkable ability to adjust their diameter to normalize the hemodynamic
characteristics of the blood flowing through them. The responses are both acute and, when …

Flow detection and calcium signalling in vascular endothelial cells

J Ando, K Yamamoto - Cardiovascular research, 2013 - academic.oup.com
Blood vessels alter their morphology and function in response to changes in blood flow, and
their responses are based on blood flow detection by the vascular endothelium. Endothelial …

Endothelial cellular response to altered shear stress

AB Fisher, S Chien, AI Barakat… - American Journal of …, 2001 - journals.physiology.org
Endothelial cells are normally exposed constantly to mechanical forces that significantly
influence their phenotype. This symposium presented recent information concerning …

Molecular aspects of signal transduction of shear stress in the endothelial cell

AM Malek, S Izumo - Molecular Reviews in Cardiovascular Medicine, 1996 - Springer
The cardiovascular system is constantly exposed to mechanical forces, which play a pivotal
role in determining its structure and function [1, 2]. In the blood vessel, anatomical …

The dynamic response of vascular endothelial cells to fluid shear stress

CF Dewey Jr, SR Bussolari, MA Gimbrone Jr… - 1981 - asmedigitalcollection.asme.org
We have developed an in-vitro system for studying the dynamic response of vascular
endothelial cells to controlled levels of fluid shear stress. Cultured monolayers of bovine …

Effects of fluid shear stress on gene regulation of vascular cells

M Papadaki, SG Eskin - Biotechnology progress, 1997 - Wiley Online Library
Hemodynamic forces such as fluid shear stress play an active role in many physiological
and pathophysiological processes of the cardiovascular system. Shear stress resulting from …

Responsiveness of vascular endothelium to shear stress: potential role of ion channels and cellular cytoskeleton

AI Barakat - International journal of molecular medicine, 1999 - spandidos-publications.com
The frictional forces associated with blood flow expose vascular endothelium in arteries to a
complex and highly dynamic shear stress distribution. The ability of endothelial cells to …