Mitochondrial contributions to tissue damage in stroke
NR Sims, MF Anderson - Neurochemistry international, 2002 - Elsevier
Tissue infarction, involving death of essentially all cells within a part of the brain, is a
common pathology resulting from stroke and an important determinant of the long-term …
common pathology resulting from stroke and an important determinant of the long-term …
[HTML][HTML] Mitochondria, oxidative metabolism and cell death in stroke
NR Sims, H Muyderman - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …
[HTML][HTML] Diverse roles of mitochondria in ischemic stroke
Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …
developed countries. The current best practices for patients with acute ischemic stroke …
Mitochondrial respiratory function and cell death in focal cerebral ischemia
MF Anderson, NR Sims - Journal of neurochemistry, 1999 - Wiley Online Library
Pyruvate‐supported oxygen uptake was determined as a measure of the functional capacity
of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion …
of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion …
The alterations in mitochondrial dynamics following cerebral ischemia/reperfusion injury
J Vongsfak, W Pratchayasakul, N Apaijai… - Antioxidants, 2021 - mdpi.com
Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …
Ultrastructural changes of neuronal mitochondria after transient and permanent cerebral ischemia
NJ Solenski, CG diPierro, PA Trimmer, AL Kwan… - Stroke, 2002 - Am Heart Assoc
Background and Purpose—Mitochondrial swelling is one of the most striking and initial
ultrastructural changes after acute brain ischemia. The purpose of the present study was to …
ultrastructural changes after acute brain ischemia. The purpose of the present study was to …
Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
K Blomgren, C Zhu, U Hallin, H Hagberg - Biochemical and biophysical …, 2003 - Elsevier
The developing and the adult brain respond in similar ways to ischemia, but also display
clear differences. For example, the relative contributions of necrosis and apoptosis to …
clear differences. For example, the relative contributions of necrosis and apoptosis to …
Role and mechanisms of secondary mitochondrial failure
Ischemia is accompanied by mitochondrial dysfunction, as assessed by measurements of
mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial …
mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial …
Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion
M Christophe, S Nicolas - Current pharmaceutical design, 2006 - ingentaconnect.com
Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …
Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: therapeutic implications
Mitochondria represent both the main source and target of reactive oxygen and nitrogen
species (RONS). In view of the large energy expenditure made by neurons during …
species (RONS). In view of the large energy expenditure made by neurons during …