Arp2/3 complex generates branched actin networks that drive fundamental processes such
as cell motility and cytokinesis. The complex comprises seven proteins, including actin …

Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell
motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3) …

Nucleation of branched actin filaments by Arp2/3 complex is tightly regulated to control actin
assembly in cells. Arp2/3 complex activation involves conformational changes brought about …

Previous structures of Arp2/3 complex, determined in the absence of a nucleation-promoting
factor and actin, reveal its inactive conformation. The study of the activated structure has …

The Arp2/3 (actin-related protein 2/3) complex nucleates branched actin filaments involved
in multiple cellular functions, including endocytosis and cellular motility. Two subunits (Arp2 …

Actin nucleation and branching by the Arp2/3 complex is tightly regulated by activating
factors. However, the mechanism of Arp2/3 complex activation remains unclear. We used …

The Arp2/3 complex is comprised of seven evolutionarily conserved subunits and upon
activation by WASp or another nucleation promoting factor nucleates the formation of actin …

Arp2/3 complex nucleates branched actin filaments important for processes such as DNA
repair, endocytosis, and cellular motility. Multiple factors are required to activate branching …

The Arp2/3 complex polymerizes new actin filaments from the sides of existing filaments,
forming Y-branched networks that are critical for actin-mediated force generation. Binding of …

Arp2/3 complex initiates the growth of branched actin‐filament networks by inducing actin
polymerization from the sides of pre‐existing filaments. Nucleation promoting factors (NPFs) …