Improving generalizability and study design of Alzheimer's disease cohort studies in the United States by including under‐represented populations
MR Mindt, O Okonkwo, MW Weiner… - Alzheimer's & …, 2023 - Wiley Online Library
The poor generalizability of clinical research data due to the enrollment of highly educated,
non‐Latinx White participants hampers the development of therapies for Alzheimer's …
non‐Latinx White participants hampers the development of therapies for Alzheimer's …
Challenges and considerations related to studying dementia in Blacks/African Americans
Blacks/African Americans have been reported to be∼ 2–4 times more likely to develop
clinical Alzheimer's disease (AD) compared to Whites. Unfortunately, study design …
clinical Alzheimer's disease (AD) compared to Whites. Unfortunately, study design …
Underrepresentation of African-Americans in Alzheimer's trials: a call for affirmative action
J Shin, PM Doraiswamy - Frontiers in aging neuroscience, 2016 - frontiersin.org
Personalized medicine aims to tailor diagnosis and treatment based on an individual's
personal genetic make-up and other predictive biomarkers—rather than a one-size fits all …
personal genetic make-up and other predictive biomarkers—rather than a one-size fits all …
Disparities by race and ethnicity among adults recruited for a preclinical Alzheimer disease trial
R Raman, YT Quiroz, O Langford, J Choi… - JAMA Network …, 2021 - jamanetwork.com
Importance Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD)
clinical trials limits generalizability of results and hinders opportunities to examine potential …
clinical trials limits generalizability of results and hinders opportunities to examine potential …
Modifiable barriers for recruitment and retention of older adults participants from underrepresented minorities in Alzheimer's disease research
KK Indorewalla, MK O'Connor… - Journal of …, 2021 - content.iospress.com
Clinical Alzheimer's disease (AD) trials currently face a critical shortfall of thousands of
eligible participants, which inflates the duration and cost of the clinical study as well as …
eligible participants, which inflates the duration and cost of the clinical study as well as …
Representativeness of samples enrolled in Alzheimer's disease research centers
M Arce Rentería, TM Mobley… - Alzheimer's & …, 2023 - Wiley Online Library
To generalize findings on the mechanisms and prognosis in Alzheimer's disease and
related dementias (ADRD), it is critical for ADRD research to be representative of the …
related dementias (ADRD), it is critical for ADRD research to be representative of the …
Estimating prevalence of early Alzheimer's disease in the United States, accounting for racial and ethnic diversity
C Gillis, P Montenigro, M Nejati… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Updated estimates of the US Alzheimer's disease (AD) population, including
under‐represented populations, are needed to improve clinical trial diversity. Methods A …
under‐represented populations, are needed to improve clinical trial diversity. Methods A …
Barriers and solutions to Alzheimer's disease clinical trial participation for Black Americans
J Savold, M Cole, RJ Thorpe Jr - Alzheimer's & Dementia …, 2023 - Wiley Online Library
Abstract Introduction Black Americans are disproportionately burdened by Alzheimer's
disease (AD) relative to other racial groups in the United States and continue to be …
disease (AD) relative to other racial groups in the United States and continue to be …
Challenging assumptions about African American participation in Alzheimer disease trials
Objective The authors investigated potential effects of increased African American
participation in Alzheimer disease (AD) and mild cognitive impairment (MCI) clinical trials by …
participation in Alzheimer disease (AD) and mild cognitive impairment (MCI) clinical trials by …
Inclusion of underrepresented groups in preclinical Alzheimer disease trials—opportunities abound
In the search for treatments to delay or halt the progression of Alzheimer disease (AD),
researchers see promise in clinical trials that enroll people without cognitive decline who …
researchers see promise in clinical trials that enroll people without cognitive decline who …