Improving generalizability and study design of Alzheimer's disease cohort studies in the United States by including under‐represented populations

MR Mindt, O Okonkwo, MW Weiner… - Alzheimer's & …, 2023 - Wiley Online Library
The poor generalizability of clinical research data due to the enrollment of highly educated,
non‐Latinx White participants hampers the development of therapies for Alzheimer's …

Challenges and considerations related to studying dementia in Blacks/African Americans

ET Ighodaro, PT Nelson, WA Kukull… - Journal of …, 2017 - content.iospress.com
Blacks/African Americans have been reported to be∼ 2–4 times more likely to develop
clinical Alzheimer's disease (AD) compared to Whites. Unfortunately, study design …

Underrepresentation of African-Americans in Alzheimer's trials: a call for affirmative action

J Shin, PM Doraiswamy - Frontiers in aging neuroscience, 2016 - frontiersin.org
Personalized medicine aims to tailor diagnosis and treatment based on an individual's
personal genetic make-up and other predictive biomarkers—rather than a one-size fits all …

Disparities by race and ethnicity among adults recruited for a preclinical Alzheimer disease trial

R Raman, YT Quiroz, O Langford, J Choi… - JAMA Network …, 2021 - jamanetwork.com
Importance Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD)
clinical trials limits generalizability of results and hinders opportunities to examine potential …

Modifiable barriers for recruitment and retention of older adults participants from underrepresented minorities in Alzheimer's disease research

KK Indorewalla, MK O'Connor… - Journal of …, 2021 - content.iospress.com
Clinical Alzheimer's disease (AD) trials currently face a critical shortfall of thousands of
eligible participants, which inflates the duration and cost of the clinical study as well as …

Representativeness of samples enrolled in Alzheimer's disease research centers

M Arce Rentería, TM Mobley… - Alzheimer's & …, 2023 - Wiley Online Library
To generalize findings on the mechanisms and prognosis in Alzheimer's disease and
related dementias (ADRD), it is critical for ADRD research to be representative of the …

Estimating prevalence of early Alzheimer's disease in the United States, accounting for racial and ethnic diversity

C Gillis, P Montenigro, M Nejati… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Updated estimates of the US Alzheimer's disease (AD) population, including
under‐represented populations, are needed to improve clinical trial diversity. Methods A …

Barriers and solutions to Alzheimer's disease clinical trial participation for Black Americans

J Savold, M Cole, RJ Thorpe Jr - Alzheimer's & Dementia …, 2023 - Wiley Online Library
Abstract Introduction Black Americans are disproportionately burdened by Alzheimer's
disease (AD) relative to other racial groups in the United States and continue to be …

Challenging assumptions about African American participation in Alzheimer disease trials

RE Kennedy, GR Cutter, G Wang… - The American Journal of …, 2017 - Elsevier
Objective The authors investigated potential effects of increased African American
participation in Alzheimer disease (AD) and mild cognitive impairment (MCI) clinical trials by …

Inclusion of underrepresented groups in preclinical Alzheimer disease trials—opportunities abound

JJ Manly, A Gilmore-Bykovskyi, KD Deters - JAMA Network Open, 2021 - jamanetwork.com
In the search for treatments to delay or halt the progression of Alzheimer disease (AD),
researchers see promise in clinical trials that enroll people without cognitive decline who …