The efficacy of paclitaxel (PTX) is limited due to its poor solubility, poor bioavailability, and
acquired drug resistance mechanisms. Designing paclitaxel prodrugs can improve its …

Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs,
particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is …

Chemotherapy has occupied the critical position in cancer therapy, especially towards the
post-operative, advanced, recurrent, and metastatic tumors. Paclitaxel (PTX)-based …

This study presents the combination of the prodrug approach with the self-assembly
technique by using a poly (ethylene glycol)–paclitaxel (PTX) conjugate as the nanomicellar …

The macromonomer method was used to prepare cross-linked, paclitaxel-loaded polylactide
(PLA)–polyethylene glycol (stealth) nanoparticles using free-radical dispersion …

With the development of nanomedicine, studies focus on self-assembled nanoplatforms to
reduce the toxicity of paclitaxel (PTX), promote the immune function at low-toxicity PTX, and …

Recent studies focused on the nanodelivery system of paclitaxel (Ptx) to overcome the poor
solubility and hypersensitivity of Ptx caused by the application of Cremophor EL as a …

The main challenge encountered while treating using Paclitaxel (PTX) is its poor solubility in
aqueous solutions. The cremophor used in the formulation can cause various side effects …

A series of paclitaxel prodrugs designed for formulation in lipophilic nanoparticles are
described. The hydrophobicity of paclitaxel was increased by conjugating a succession of …

Purpose The objective of this study was to develop a custom-tailored polymeric drug
delivery system for paclitaxel, employing a novel biodegradable block co-polymer (P) …