Aim: The effect of coumarin derivatives on melanogenesis was investigated in B16 murine
melanoma cells. Methods: Melanin content and tyrosinase activity were analyzed …

Scopoletin was recently shown to stimulate melanogenesis through cAMP-response
element-binding protein (CREB) phosphorylation. In this study, we investigated the …

The objectives of this study were to investigate the melanogenetic potentials of the naturally
occurring 7-hydroxy coumarin derivatives 7-hydroxy 5, 6-dimethoxycoumarin (7H-5, 6DM), 7 …

Tyrosinase and its transcriptional regulator microphthalmia-associated transcription factor
(MITF) play critical roles in regulation of melanogenesis, and are required for environmental …

In the present study, we investigated the effect of guggulsterone on melanogenesis in B16
melanoma cells and elucidated its possible mechanism of action. The effects of …

Melanogenesis in melanoma cells can be enhanced by psoralens in the absence of UV
light. Melanin biosynthesis is regulated by a number of melanocyte‐specific proteins …

Quercetin is known to inhibit tyrosinase activity and melanin production in melanocytes.
However, several reports suggest that quercetin has different and opposite effects on …

Aim: To investigate the effect of [6]-shogaol, an active ingredient in ginger, on
melanogenesis and the underlying mechanisms. Methods: B16F10 mouse melanoma cells …

Melanogenesis is a physiological process that results in the synthesis of melanin pigments,
which play a crucial protective role against skin photocarcinogenesis. In order to determine …

We investigated the effects of four coumarin derivatives, namely, 6-methylcoumarin, 7-
methylcoumarin, 4-hydroxy-6-methylcoumarin, and 4-hydroxy-7-methylcoumarin, which …