It has long been proposed that recapitulating the extracellular matrix (ECM) of native human
tissues in the laboratory may enhance the regenerative capacity of engineered scaffolds in …

Bone tissue engineers are facing a daunting challenge when attempting to fabricate bigger
constructs intended for use in the treatment of large bone defects, which is the …

Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a
particular challenge in engineering tissues suitable for repairing large bone defects. To …

The native extracellular matrix (ECM) is a complex gel-like system with a broad range of
structural features and biomolecular signals. Hydrogel platforms that can recapitulate the …

Bioprinting can be considered as a progression of the classical tissue engineering
approach, in which cells are randomly seeded into scaffolds. Bioprinting offers the …

For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective
prevascularisation strategies are required to provide the necessary nutrients for normal …

Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only
responsible for the formation of the strongly divergent tissue types but also for their …

Bone is a highly vascularized tissue with a unique and complex structure. Long bone
consists of a peripheral cortical shell containing a network of channels for vascular …

An extracellular matrix (ECM) utilized as a biomaterial can be obtained from organs of living
organisms. Therefore, it has some limitations in its supply because of insufficient organs …

Efficient vascularization within a scaffold is an essential criterion for evaluating the success
of volumetric bone formation. Various strategies using angiogenic growth factors and cell …