Trehalose-deficient Acinetobacter baumannii exhibits reduced virulence by losing capsular polysaccharide and altering membrane integrity

CS Crippen, J Glushka, E Vinogradov… - …, 2021 - academic.oup.com
Acinetobacter baumannii has become a leading cause of bacterial nosocomial infections, in
part, due to its ability to resist desiccation, disinfection and antibiotics. Several factors …

Trehalose, a temperature‐ and salt‐induced solute with implications in pathobiology of Acinetobacter baumannii

S Zeidler, J Hubloher, K Schabacker… - Environmental …, 2017 - Wiley Online Library
Acinetobacter baumannii is an opportunistic human pathogen that has become a global
threat to healthcare institutions worldwide. A major factor contributing to success of this …

Trehalose‐6‐phosphate‐mediated phenotypic change in Acinetobacter baumannii

JJ Hubloher, S Zeidler, P Lamosa… - Environmental …, 2020 - Wiley Online Library
The stress protectant trehalose is synthesized in Acinetobacter baumannii from UPD‐
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that …

[HTML][HTML] Identification of a General O-linked Protein Glycosylation System in Acinetobacter baumannii and Its Role in Virulence and Biofilm Formation

JA Iwashkiw, A Seper, BS Weber, NE Scott… - PLoS …, 2012 - journals.plos.org
Acinetobacter baumannii is an emerging cause of nosocomial infections. The isolation of
strains resistant to multiple antibiotics is increasing at alarming rates. Although A. baumannii …

Trehalose and bacterial virulence

M Vanaporn, RW Titball - Virulence, 2020 - Taylor & Francis
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …

[HTML][HTML] Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa

SD Woodcock, K Syson, RH Little, D Ward… - PLoS …, 2021 - journals.plos.org
An important prelude to bacterial infection is the ability of a pathogen to survive
independently of the host and to withstand environmental stress. The compatible solute …

The trehalose-specific transporter LpqY-SugABC is required for antimicrobial and anti-biofilm activity of trehalose analogues in Mycobacterium smegmatis

JM Wolber, BL Urbanek, LM Meints, BF Piligian… - Carbohydrate …, 2017 - Elsevier
Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess
distinctive pathways for synthesizing and utilizing the non-mammalian disaccharide …

The role of compatible solutes in desiccation resistance of Acinetobacter baumannii

S Zeidler, V Müller - Microbiologyopen, 2019 - Wiley Online Library
Acinetobacter baumannii is a nosocomial pathogen which can persist in the hospital
environment not only due to the acquirement of multiple antibiotic resistances, but also …

[HTML][HTML] Trehalose metabolism: A sweet spot for Burkholderia pseudomallei virulence

S Schwarz, P Van Dijck - Virulence, 2017 - Taylor & Francis
Trehalose is a sugar composed of 2 aD-glucose molecules linked by an a, a-1, 1-glucoside
bond which is produced by a variety of organisms such as bacteria, archeae, fungi, plants …

[HTML][HTML] Diversity and function of capsular polysaccharide in Acinetobacter baumannii

JK Singh, FG Adams, MH Brown - Frontiers in microbiology, 2019 - frontiersin.org
The Gram-negative opportunistic bacterium Acinetobacter baumannii is a significant cause
of hospital-borne infections worldwide. Alarmingly, the rapid development of antimicrobial …