The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

Numerous individuals suffer from impaired wound healing, such as chronic ulcers, severe
burns and immune disorders, resulting in both public health and economic burdens. Skin is …

Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

To set the scene for this Directed Issue on Mechanisms of Tissue Repair of The International
Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the …

Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

Human skin is a remarkably plastic organ that sustains insult and injury throughout life. Its
ability to expeditiously repair wounds is paramount to survival and is thought to be regulated …

Tissue repair after injury is a complex, metabolically demanding process. Depending on the
tissue's regenerative capacity and the quality of the inflammatory response, the outcome is …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Highlights•Multiple cell lineages reprogram and migrate in order to heal a wound.•In
general, wound healing cell behaviours appear to recapitulate development.•Inflammation …

Wounds, both chronic and acute, continue to be a tremendous socioeconomic burden. As
such, technologies drawn from many disciplines within science and engineering are …