Background To date, outcome data with a large sample size and data regarding the clinical
outcomes of pharmacokinetic-guided (PK) dosing of vancomycin are limited. Aim We …

Background: Various pharmacokinetic (PK) equations and software have been developed to
individualize vancomycin dosing. However, the benefit of using any PK information to guide …

Background: Therapeutic vancomycin trough levels correlate with therapeutic success and
the development of renal failure. In this study, we aimed to describe the safety and outcome …

Study Objective The optimal pharmacodynamic parameter for the prediction of efficacy of
vancomycin is the area under the concentration–time curve (AUC), and current published …

Purpose: Vancomycin prescribing requires individualized dosing and monitoring to ensure
efficacy, limit toxicity, and minimize resistance. Although there are nationally endorsed …

Background Dosing vancomycin to achieve target concentrations of 15 to 20 mg/L has been
recommended for select infections. To date, few vancomycin nomograms designed to target …

Background: Consensus guidelines recommend vancomycin doses of 15 to 20 mg/kg every
8 to 12 hours in patients with normal renal function. Objective: To evaluate the effect of a …

Vancomycin is an antibiotic for exclusive hospital use administrated in intravenous infusion
to treat systemic infections. It is mainly eliminated by kidneys and potentially nephrotoxic …

Background: To increase target attainment rates, switching the mode of administration from
intermittent (InI) to continuous infusion (CoI) has been proposed. In this study, target …

Introduction The clinical application of continuous infusion (CoI) of vancomycin has gained
interest in recent years. Since no international guidelines on initial dosing of vancomycin CoI …