[HTML][HTML] Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors

AL Lin, VA Rudneva, AL Richards, Y Zhang… - Acta …, 2024 - Springer
Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory
behavior are the rare subset that progress after surgery, conventional medical therapies …

Pituitary tumors: genetic and molecular factors underlying pathogenesis and clinical behavior

A Spada, G Mantovani, AG Lania, D Treppiedi… - …, 2022 - karger.com
Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neoplasms.
Although generally benign, they can show a clinically aggressive course, with local invasion …

Genomics and epigenomics of pituitary tumors: what do pathologists need to know?

SL Asa, O Mete, S Ezzat - Endocrine pathology, 2021 - Springer
Molecular pathology has advanced our understanding of many tumors and offers
opportunities to identify novel therapies. In the pituitary, the field has uncovered several …

Clinical identification of oncogenic drivers and copy-number alterations in pituitary tumors

WL Bi, NF Greenwald, SH Ramkissoon… - …, 2017 - academic.oup.com
Pituitary tumors are the second most common adult primary brain tumor, with a variable
clinical course. Recent work has identified a number of genetic determinants of pituitary …

Epigenomic and somatic mutation profile of pituitary adenomas (PAs)/pituitary neuroendocrine tumors (PitNETs)

F Guaraldi, L Morandi, M Zoli, A Righi… - Endocrine …, 2022 - endocrine-abstracts.org
Background: Pituitary adenomas (PAs)/Pituitary Neuroendocrine Tumors (PitNETs) are a
complex and heterogeneous group of lesions. Genetic and epigenetic studies have been …

[HTML][HTML] Transcriptomic profiles of normal pituitary cells and pituitary neuroendocrine tumor cells

JY Oh, RC Osorio, J Jung, L Carrete, N Choudhary… - Cancers, 2022 - mdpi.com
Simple Summary The molecular pathogenesis of pituitary neuroendocrine tumors (PitNETs)
involves the interplay of many genes and transcription factors in the setting of a diverse …

SAT603 A Heterogeneous Genetic Background Underlies Familial And Young-onset Pituitary Tumors

JM Zuarth-Vazquez, RG Rebollar-Vega… - Journal of the …, 2023 - academic.oup.com
Abstract Disclosure: JM Zuarth-Vazquez: None. RG Rebollar-Vega: None. C. Ramírez-
Rentería: None. WE Hernández-Núñez: None. M. Torres-Morán: None. AL Franco-Álvarez …

[HTML][HTML] Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors

R Peculis, V Rovite, K Megnis, I Balcere, A Breiksa… - Plos one, 2022 - journals.plos.org
Somatic genetic alterations in pituitary neuroendocrine tumors (PitNET) tissues have been
identified in several studies, but detection of overlapping somatic PitNET candidate genes is …

[HTML][HTML] Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

H Lasolle, MH Elsensohn, A Wierinckx, E Alix… - Acta neuropathologica …, 2020 - Springer
The purpose of this study was to analyze the impact of copy number variations (CNV) on
sporadic pituitary neuroendocrine tumors (PitNETs) prognosis, to identify specific prognosis …

Landscape of genomic alterations in pituitary adenomas

WL Bi, P Horowitz, NF Greenwald, M Abedalthagafi… - Clinical Cancer …, 2017 - AACR
Purpose: Pituitary adenomas are the second most common primary brain tumor, yet their
genetic profiles are incompletely understood. Experimental Design: We performed whole …