We evaluated the possibility of using Yersinia pseudotuberculosis as a live vaccine against
plague because it shares high genetic identity with Y. pestis while being much less virulent …

Yersinia pestis, the agent of plague, is among the deadliest bacterial pathogens affecting
humans, and is a potential biological weapon. Because antibiotic resistant strains of …

In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain
(χ10069) engineered with Δ yopK Δ yopJ Δ asd triple mutations was used to deliver a Y …

Background Plague is still a public health problem in the world and is re-emerging, but no
efficient vaccine is available. We previously reported that oral inoculation of a live attenuated …

Abstract A Yersinia pseudotuberculosis PB1+ (Yptb PB1+) mutant strain combined with
chromosome insertion of the caf1R-caf1A-caf1M-caf1 operon and deletions of yopJ and …

ABSTRACT A newly attenuated Yersinia pseudotuberculosis strain (designated Yptb1) with
triple mutation Δ asd Δ yopK Δ yopJ and chromosomal insertion of the Y. pestis caf1R-caf1M …

Immunization with the live-attenuated Yersinia pseudotuberculosis VTnF1 strain producing a
Yersinia pestis F1 pseudocapsule efficiently protects mice against bubonic and pneumonic …

Yersinia pestis (YP), the gram-negative plague bacterium, has shaped human history unlike
any other pathogen known to mankind. YP (transmitted by the bite of an infected flea) …

A single oral inoculation to mice of the live attenuated Yersinia pseudotuberculosis VTnF1
strain producing an F1 pseudocapsule protects against bubonic and pneumonic plague …

Yersinia pestis biovar Microtus is considered to be a virulent to larger mammals, including
guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine …