Anti-inflammatory effects of Melatonin: A mechanistic review

SM Nabavi, SF Nabavi, A Sureda, J Xiao… - Critical reviews in …, 2019 - Taylor & Francis
Abstract N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by
plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In …

Plant-derived melatonin from food: a gift of nature

G Cheng, T Ma, Z Deng, G Gutiérrez-Gamboa, Q Ge… - Food & Function, 2021 - pubs.rsc.org
In recent years, people have become increasingly interested in bioactive ingredients from
plants, especially antioxidant molecules such as melatonin, which are beneficial to human …

Role of melatonin in the inflammatory process and its therapeutic potential

L Carrascal, P Nunez-Abades, A Ayala… - Current …, 2018 - ingentaconnect.com
Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Melatonin: a pleiotropic molecule regulating inflammation

F Radogna, M Diederich, L Ghibelli - Biochemical pharmacology, 2010 - Elsevier
Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials

JH Cho, S Bhutani, CH Kim, MR Irwin - Brain, behavior, and immunity, 2021 - Elsevier
Chronic inflammation contributes to multiple diseases including cardiovascular diseases,
autoimmune disorders, metabolic disorders, and psychiatric conditions. Melatonin, a …

Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug

R Hardeland, SR Pandi-Perumal - Nutrition & metabolism, 2005 - Springer
Melatonin, originally discovered as a hormone of the pineal gland, is also produced in other
organs and represents, additionally, a normal food constituent found in yeast and plant …

Melatonin in medicinal and food plants: occurrence, bioavailability, and health potential for humans

B Salehi, F Sharopov, PVT Fokou, A Kobylinska… - Cells, 2019 - mdpi.com
Melatonin is a widespread molecule among living organisms involved in multiple biological,
hormonal, and physiological processes at cellular, tissue, and organic levels. It is well …

Melatonin and inflammation—Story of a double‐edged blade

R Hardeland - Journal of pineal research, 2018 - Wiley Online Library
Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials

M Zarezadeh, M Khorshidi, M Emami… - European journal of …, 2020 - Springer
Background Inflammatory processes are involved in chronic diseases. It has been
suggested that melatonin reduces inflammation by its radical scavenging properties; …

Melatonin and related compounds: Antioxidant and anti-inflammatory actions

M Bantounou, J Plascevic, HF Galley - Antioxidants, 2022 - mdpi.com
Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland and
other tissues [1, 2] is a potent antioxidant and inflammatory agent [1]. Specifically, the …