Insulin reactions occur rarely but are of tremendous clinical importance. The first was
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …

While immunologic responses to insulin such as cutaneous reactivity and antibody against
insulin are common significant clinical problems related to those immunologic reactions are …

An allergic reaction develops in 2.4% of patients that use insulin. This ranges in severity
from erythema and pruritus to life-threatening anaphylaxis. llergic reactions to insulin usually …

Although the incidence of insulin allergy decreased after the introduction of recombinant
human insulin preparations, it is still a major problem which may be life-threatening in some …

DISCUSSION Dr. Grammer: Whenever a patient on insulin develops a generalized urticarial
reaction like patient 1, the question of insulin allergy is likely to arise. The differential …

Allergy to insulin is rare with human recombinant insulin and is now reported for< 1% of
diabetic patients. Clinic symptoms are usually local and appear a few minutes after the …

The prevalence of insulin allergy has considerably decreased with the availability of human
recombinant insulins, and the disorder is now rare, although well described. Insulin allergy …

We reevaluated IgE-mediated insulin allergy using sera obtained 16 to 21 years ago and, 1
and 5 years ago. All antibodies had specificity for human and bovine insulin. We …

Background Although allergic reactions to insulin are uncommon, they can be difficult to
diagnose and management may be very difficult in subjects with Type 1 diabetes with …

Two of five patients with acute systemic allergic reactions to insulin injection required
desensitization. Immunologic studies consisted of direct skin testing with a variety of insulins …