There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

The antimicrobial resistance crisis is a global health issue requiring discovery and
development of novel therapeutics. However, conventional screening of natural products or …

Antimicrobial drug resistance is a growing threat to global public health. Multidrug resistance
among the'ESKAPE'organisms—encompassing Enterococcus faecium, Staphylococcus …

Antimicrobial resistance in clinically important microbes has emerged as an unmet
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …

Highlights•Adjuvants potentiate existing antibiotics or combat mechanisms of
resistance.•Probes enable the identification of enzymes that modify tuberculosis …

Antibiotic resistance is a problem that continues to challenge the healthcare sector. In
particular, multidrug resistance is now common in familiar pathogens such as …

The global threat of antibiotic resistance is steadily growing. Antibiotic resistance may
involve any class of antibiotic, including second-and third-line agents that have been …

3235 https://dx. doi. org/10.1021/acs. chemrev. 1c00118 Chem. Rev. 2021, 121, 3235− 3237
drugs often optimized with structure-based strategies. They describe the approaches that …

Antibiotics effective against Gram‐negative ESKAPE pathogens are a critical area of unmet
need. Infections caused by these pathogens are not only difficult to treat but finding new …

Antibiotic resistance poses an immediate and growing threat to human health. Multidrug
efflux pumps are promising targets for overcoming antibiotic resistance with small-molecule …