Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and
extraterminal (BET) family, is considered to be a major driver of cancer cell growth and a …

Bromodomain (BRD) and extra-terminal (BET) proteins are epigenetic readers that regulate
gene expression and promote cancer evolution. Pharmacological inactivation of BRD4 has …

BRD7 is a potential nuclear transcription regulation factor related to nasopharyngeal
carcinoma (NPC). BRD2, a putative BRD7-interacting protein, has been screened from …

Although the significance of BRD4 in the epigenetic memory and cancer genesis has been
intensively investigated, little is known about its function and potential roles during the …

BRD7 functions as a crucial tumor suppressor in numerous malignancies. However, the
effects of BRD7 on colorectal cancer (CRC) progression are still unknown. Here, based on …

Bromodomain-containing protein 4 (Brd4) plays an important role in mediating the
expression of genes involved in cancers and non-cancer diseases such as inflammatory …

The epigenetic reader BRD4 plays a vital role in transcriptional regulation, cellular growth
control, and cell-cycle progression. Dysregulation of BRD4 function has been implicated in …

Abstract BRD7 (bromodomain 7), also known as celtix-1, was first identified in
nasopharyngeal carcinoma (NPC) cells in 2000. BRD7 is a crucial component of both …

Background: Bromodomain-containing protein 4 (BRD4) is reported to play a vital role in the
development of numerous malignant diseases, which is considered as a promising target for …