Although the measurement of aminoglycosides and glycopeptides in blood has been well
established, it has become evident that therapeutic drug monitoring (TDM) should be …

Antibiotics are among the medications most frequently administered to the critically ill, a
population with high levels of intra-and inter-individual pharmacokinetic variability. Our …

Therapeutic drug monitoring (TDM) is a clinical science centered around the quantification
of drug concentrations in body fluids. To be considered candidates for TDM drugs must …

Potential under-or overdose of antibiotics may occur in intensive care units due to high
variability in plasma concentrations. The risk is either treatment failure or toxicity. Thus …

High mortality and morbidity rates associated with severe infections in the critically ill
continue to be a significant issue for the healthcare system. In view of the diverse and …

Purpose: Early initiation of antibiotics is essential for ameliorating infections in critically ill
patients. The correct dosage of antibiotics is imperative to ensure their adequate exposure …

The basic principle of therapeutic drug monitoring (TDM) is the quantification of drug
concentrations in body fluids, mostly from venous blood samples, for optimizing drug …

Background: Aminoglycosides require highly accurate therapeutic drug monitoring owing to
their narrow therapeutic windows and toxic side effects. Therapeutic drug monitoring varies …

Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Background and aims Intensive care antibiotic treatment faces challenges due to substantial
pharmacokinetic differences in critically ill patients. Individualized antibiotic dosing guided …