[HTML][HTML] No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment

RA Crockett, KB Wilkins, S Aditham… - Neurobiology of …, 2023 - Elsevier
Background Approximately one third of recently diagnosed Parkinson's disease (PD)
patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates …

Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease

H Wilson, ER de Natale, M Politis - Handbook of Clinical Neurology, 2021 - Elsevier
Abstract Cognitive impairment affects approximately 20%–50% of patients with Parkinson's
disease (PD), with a higher prevalence as the disease advances. The nucleus basalis of …

Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease

J Schulz, G Pagano, JA Fernández Bonfante, H Wilson… - Brain, 2018 - academic.oup.com
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We
hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion …

[HTML][HTML] Meynert nucleus-related cortical thinning in Parkinson's disease with mild cognitive impairment

S Rong, Y Li, B Li, K Nie, P Zhang, T Cai… - … Imaging in Medicine …, 2021 - ncbi.nlm.nih.gov
Background Cognitive impairment in Parkinson's disease (PD) involves the cholinergic
system and cholinergic neurons, especially the nucleus basalis of Meynert (NBM/Ch4) …

[HTML][HTML] Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease

JB Pereira, S Hall, M Jalakas, MJ Grothe… - Neurobiology of …, 2020 - Elsevier
Objectives Cholinergic dysfunction plays a prominent role in cognitive impairment in
Parkinson's disease (PD). The aim of this study was to assess the relationship of baseline …

Lower volume, more impairment: reduced cholinergic basal forebrain grey matter density is associated with impaired cognition in Parkinson disease

MJ Barrett, SA Sperling, JC Blair… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective A major contributor to dementia in Parkinson disease (PD) is degeneration of the
cholinergic basal forebrain. This study determined whether cholinergic nucleus 4 (Ch4) …

In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease

NJ Ray, S Bradburn, C Murgatroyd, U Toseeb, P Mir… - Brain, 2018 - academic.oup.com
Abstract See Gratwicke and Foltynie (doi: 10.1093/brain/awx333) for a scientific commentary
on this article. Cognitive impairments are a prevalent and disabling non-motor complication …

[HTML][HTML] In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

MJ Grothe, MA Labrador-Espinosa, S Jesús… - Parkinsonism & Related …, 2021 - Elsevier
Introduction We aimed to assess associations between multimodal neuroimaging measures
of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) …

Frontostriatal and limbic contributions to cognitive decline in Parkinson's disease

G Brown, J Hakun, MM Lewis, S De Jesus… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose The circuitry underlying heterogenous cognitive profiles
in Parkinson's disease (PD) remains unclear. The purpose of this study is to investigate …

Early nucleus basalis of Meynert degeneration predicts cognitive decline in Parkinson's disease

JP Gratwicke, T Foltynie - Brain, 2018 - academic.oup.com
Early nucleus basalis of Meynert degeneration predicts cognitive decline in Parkinson’s disease
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