[HTML][HTML] Curcumin: An epigenetic regulator and its application in cancer

T Ming, Q Tao, S Tang, H Zhao, H Yang, M Liu… - Biomedicine & …, 2022 - Elsevier
Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

AB Kunnumakkara, D Bordoloi, C Harsha… - Clinical …, 2017 - portlandpress.com
Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and
Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical …

New insights into therapeutic activity and anticancer properties of curcumin

AK Panda, D Chakraborty, I Sarkar… - Journal of experimental …, 2017 - Taylor & Francis
Natural compounds obtained from plants are capable of garnering considerable attention
from the scientific community, primarily due to their ability to check and prevent the onset …

Development of curcumin as an epigenetic agent

S Fu, R Kurzrock - Cancer, 2010 - Wiley Online Library
The clinical benefits of curcumin as a single agent were demonstrated in patients with
advanced pancreatic cancer in a phase 2 study despite pharmacokinetic analysis showing a …

Molecular targets of curcumin for cancer therapy: an updated review

PD Kasi, R Tamilselvam, K Skalicka-Woźniak… - Tumor Biology, 2016 - Springer
In recent years, natural edible products have been found to be important therapeutic agents
for the treatment of chronic human diseases including cancer, cardiovascular disease, and …

Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways

AH Rahmani, MA Al Zohairy, SM Aly… - BioMed research …, 2014 - Wiley Online Library
Cancer is the most dreadful disease worldwide in terms of morbidity and mortality. The exact
cause of cancer development and progression is not fully known. But it is thought that cancer …

Anticancer activity of curcumin and its analogues: preclinical and clinical studies

A Allegra, V Innao, S Russo, D Gerace… - Cancer …, 2017 - Taylor & Francis
Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-
inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides …

Curcumin as an alternative epigenetic modulator: mechanism of action and potential effects

F Hassan, MS Rehman, MS Khan, MA Ali… - Frontiers in …, 2019 - frontiersin.org
Curcumin (a polyphenolic compound in turmeric) is famous for its potent anti-inflammatory,
anti-oxidant, and anti-cancer properties, and has a great potential to act as an epigenetic …

The multifaceted role of curcumin in cancer prevention and treatment

MK Shanmugam, G Rane, MM Kanchi, F Arfuso… - Molecules, 2015 - mdpi.com
Despite significant advances in treatment modalities over the last decade, neither the
incidence of the disease nor the mortality due to cancer has altered in the last thirty years …

Molecular mechanisms of curcumin action: signal transduction

A Shehzad, YS Lee - Biofactors, 2013 - Wiley Online Library
Chemoprevention represents one of the most highly effective anti‐cancer strategies and is
accompanied by minimal secondary effects as compared to conventional chemotherapies …