Defects in several different connexins have been associated with several different diseases.
The most common of these is deafness, where a few mutations in connexin (Cx) 26 have …

Gap junctions provide coupled cells with a direct pathway for sharing ions, nutrients, and
small metabolites, thus helping to maintain homeostasis in various tissues. Abnormal …

Gap junctions allow the exchange of ions and small molecules between adjacent cells
through intercellular channels formed by connexin proteins, which can also form functional …

Gap junctions are formed by a polygenic family of more than 20 different connexin proteins
and mediate the direct exchange of ions, metabolites and secondary messengers between …

Mutations in human connexin (Cx) genes have been related to diseases, which we termed
connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness …

Several different recessive mutations in the connexin26 (Cx26; β2) gene have been
associated with non‐syndromic hereditary deafness. This suggests gap junctions are …

Connexin 30 (Cx30) is a component of the gap junction complex. Dominant and recessive
mutations in the GJB6 gene encoding Cx30 are associated with a variety of human inherited …

Gap junctions play a critical role in hearing and mutations in connexin genes cause a high
incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap …

Connexins are the protein subunits of gap junction channels that allow a direct signaling
pathway between networks of cells. The specific role of connexin channels in the …

Connexin26 (Cx26) is a gap junction protein that oligomerizes in the cell to form hexameric
transmembrane channels called connexons. Cell surface connexons dock between …