Objectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical
industry. During the drug development process, the impact of drug supersaturation or …

Background Precipitation of poorly soluble, weakly basic drugs upon entering the small
intestine may lead to poor bioavailability. It would be useful to be able to predict the extent of …

For poorly soluble weak bases, the possibility of drug precipitation upon entry into the small
intestine may affect the amount of drug available for uptake through the intestinal mucosa. A …

Many novel small drug molecules are poorly water-soluble and thus, enabling drug
formulations may be required to ensure sufficient absorption upon oral administration …

PURPOSE: The present study investigated the interplay between supersaturation,
absorption, precipitation, and excipient-mediated precipitation inhibition by comparing …

The rate-limiting step to absorption of drugs from the gastrointestinal (GI) tract is often
dissolution from the dosage form. Consideration of the Noyes-Whitney dissolution model …

The rate-limiting step to absorption of drugs from the gastrointestinal (GI) tract is often
dissolution from the dosage form. Consideration of the Noyes-Whitney dissolution model …

The purpose of this article was two-fold: first, to optimize a recently proposed two-stage
single-compartment in vitro test for the evaluation of dissolution in the lower intestine with …

Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal
absorption for difficult-to-formulate, poorly soluble drug candidates based on a design …

The overall objective of OrBiTo, a project within Innovative Medicines Initiative (IMI), is to
streamline and optimize the development of orally administered drug products through the …