Background: Dental caries is the most prevalent bacterial biofilm-induced disease. Current
clinical prevention and treatment agents often suffer from adverse effects on oral microbiota …

Novel ecological antimicrobial approaches to dental caries focus on inhibiting cariogenic
pathogens while enhancing the growth of health-associated commensal communities or …

Oral biofilms, formed by multiple microorganisms and their extracellular polymeric
substances, seriously affect people's life. The emergence of the resistance of biofilms to …

Numerous methods have been investigated to manage dental caries, one of the top three
diseases threatening human health as reported by the World Health Organization. An …

Existing single-functional agents against dental caries are inadequate in antibacterial
performance or mineralization balance. This problem can be resolved through a novel …

Cariogenic Streptococcus mutans (S. mutans) is a leading cause of bacterial-induced oral
diseases. Current strategies to kill bacteria based on Host defense peptide (HDP) mimicking …

Purpose The interaction of Porphyromonas g ingivalis with commensal streptococci
promotes P. gingivalis colonization of the oral cavity. We previously showed that a synthetic …

Due to the complex microecology and microenvironment of dental plaque, novel caries
prevention strategies require modulating the microbial communities ecologically and …

Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has
caused serious problems due to the rapid emergence of multidrug-resistant pathogens …

Dental caries (ie, tooth decay), which is caused by biofilm formation on tooth surfaces, is the
most prevalent oral disease worldwide. Unfortunately, many anti-biofilm drugs lack efficacy …