Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis

J Xu, T Chu, T Yu, N Li, C Wang, C Li, Y Zhang… - Acs Nano, 2022 - ACS Publications
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel
disease (IBD), is responsible for dysregulation of signal transduction, inflammatory …

[HTML][HTML] Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease

M Li, J Liu, L Shi, C Zhou, M Zou, D Fu, Y Yuan, C Yao… - Bioactive Materials, 2023 - Elsevier
The excessive reactive oxygen species (ROS) is a hallmark associated with the initiation
and progression of inflammatory bowel disease (IBD), which execrably form a vicious cycle …

[HTML][HTML] A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Mannose-rich oligosaccharides-functionalized selenium nanoparticles mediates macrophage reprogramming and inflammation resolution in ulcerative colitis

H Yang, C Zhu, W Yuan, X Wei, C Liu, J Huang… - Chemical Engineering …, 2022 - Elsevier
Inflammatory bowel disease (IBD) is a global disease and usually classified into Crohn's
disease (CD) and ulcerative colitis (UC), in which the inflammatory response is known to …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

An oral nano-antioxidant for targeted treatment of inflammatory bowel disease by regulating macrophage polarization and inhibiting ferroptosis of intestinal cells

J Yang, Y Bai, S Shen, X Tao, C Ma, B Fu, Q Dai… - Chemical Engineering …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic inflammatory disease that characterized by
excessive reactive oxygen species (ROS) and high ferroptosis. The ROS plays an essential …

Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Y Chen, M Shui, Q Yuan, CT Vong, Z Yang… - Journal of Controlled …, 2023 - Elsevier
The etiology of inflammatory bowel disease (IBD) is extremely complex and related to an
excessive immune response that results in the pathologically release of reactive oxygen …

[HTML][HTML] Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

C Zhu, S Zhang, C Song, Y Zhang, Q Ling… - Journal of …, 2017 - Springer
Abstract Background Selenium (Se) is an essential micronutrient trace element and an
established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases …

[HTML][HTML] Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function …

R Ye, Q Guo, J Huang, Z Wang, Y Chen… - Journal of …, 2023 - Springer
Ulcerative colitis (UC) is currently the most common inflammatory bowel disease (IBD). Due
to its diverse and complex causes, there is no cure at present, and researchers are …

[HTML][HTML] Berberine-loaded carboxylmethyl chitosan nanoparticles ameliorate DSS-induced colitis and remodel gut microbiota in mice

L Zhao, X Du, J Tian, X Kang, Y Li, W Dai… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic and
recurrent inflammation. The progression and pathogenesis of IBD is closely related to …