The lack of reliable molecular markers for normal differentiated epithelial cells limits
understanding of human gastric carcinogenesis. Recognized precursor lesions for gastric …

BACKGROUND & AIMS: Gastric cancer evolves in the setting of a pathologic mucosal milieu
characterized by both loss of acid-secreting parietal cells and mucous cell metaplasias …

Background & Aims: Loss of gastric parietal cells is a critical precursor to gastric metaplasia
and neoplasia. However, the origin of metaplasia remains obscure. Acute parietal cell loss …

Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal
aspect of stomach function that is disrupted in precancerous lesions (eg metaplasias …

Objective Metaplasia arises from differentiated cell types in response to injury and is
considered a precursor in many cancers. Heterogeneous cell lineages are present in the …

The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain.
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …

Gastric chief cells differentiate from mucous neck cells and develop their mature state at the
base of oxyntic glands with expression of secretory zymogen granules. After parietal cell …

Intestinal‐type gastric adenocarcinoma arises in a field of pre‐existing metaplasia. While
biomarkers of cancer and metaplasia have been identified, the definition of dysplastic …

The development of intestinal-type gastric cancer is preceded by loss of parietal cells
(oxyntic atrophy) and the induction of metaplastic cell lineages in the gastric mucosa. For …

Mist1 is a basic helix‐loop‐helix transcription factor that represses E‐box‐mediated
transcription. Previous studies have suggested that the Mist1 gene is expressed in a wide …