Elucidating a basic blueprint of osteoclast-osteoblast coordination in skeletal remodeling
and understanding how this coordination breaks down with age and disease is essential for …

Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts
(OBs). Precise coordination of these activities is required for the resorbed bone to be …

Osteoclasts are multinucleated bone-resorbing cells derived from the monocyte/
macrophage lineage. The macrophage colony-stimulating factor/receptor activator of …

Osteoclasts are responsible for bone destruction in degenerative, inflammatory and
metastatic bone disorders. Although osteoclastogenesis has been well-characterized in …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

Osteoclasts are multinucleated, bone-resorbing cells formed via fusion of monocyte
progenitors, a process triggered by prolonged stimulation with RANKL, the osteoclast master …

Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …

Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as
well as bone damage under pathological conditions such as osteoporosis, arthritis …

Bone remodeling is essential for the repair and replacement of damaged and old bone. The
major principle underlying this process is that osteoclast-mediated resorption of a quantum …