The development of vaccines and other immunotherapies has been complicated by
heterogeneous antigen display and the use of incompletely defined immune adjuvants with …

Self-assembling peptides and peptide derivatives have received significant interest for
several biomedical applications, including tissue engineering, wound healing, cell delivery …

Despite the undeniable success of vaccination programs in preventing diseases, effective
vaccines against several life-threatening infectious pathogens such as human …

Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides
self-assemble into elongated nanofibers composed almost entirely of α-helical structure. The …

Biomaterials are receiving increased attention as vaccine adjuvants owing to their chemical
and compositional definition and their ability to stimulate immune responses against a …

Vaccines that elicit robust CD8+ T cell responses are desirable for protection against
infectious diseases and cancers. However, most vaccine adjuvants fail to elicit robust CD8+ …

Several different self-assembling peptide systems that form nanofibers have been
investigated as vaccine platforms, but design principles for adjusting the character of the …

Self-assembling peptides and peptide derivatives bearing cell-binding ligands are
increasingly being investigated as defined cell culture matrices and as scaffolds for …

To be optimally effective, peptide-based vaccines need to be administered with adjuvants.
Many currently available adjuvants are toxic, not biodegradable; they invariably invoke …