Background: Lynch syndrome (LS) due to an inherited damaging mutation in mismatch
repair (MMR) genes comprises 3% of all incident colorectal cancer (CRC). Molecular testing …

Background Lynch syndrome is the most common cause of hereditary colorectal cancer
(CRC) and confers increased risk of other cancers. Identification of patients improves …

Lynch syndrome (LS) accounts for around 3% of colorectal cancers (CRCs) and is caused
by germline mutations in mismatch repair (MMR) genes. Recently, screening strategies to …

The prevalence of Lynch syndrome (LS) varies significantly in different populations,
suggesting that ethnic features might play an important role. We enrolled 3330 consecutive …

Background Strategies to screen colorectal cancers (CRCs) for Lynch syndrome are
evolving rapidly; the optimal strategy remains uncertain. Aim We compared targeted versus …

Background The selection of patients for genetic testing to rule out Lynch syndrome is
currently based on fulfilment of at least one of the revised Bethesda criteria followed by …

Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …

Objective: To investigate the performance of tumor testing approaches in the identification of
Lynch syndrome (LS) in a single-center cohort of people with colorectal cancer (CRC) …

BACKGROUND: Lynch syndrome (LS), defined by a deleterious (pathogenic) germline
mutation in a mismatch repair (MMR) gene, is characterized by early age-of-onset colorectal …

BACKGROUND: Germline mutations in DNA mismatch repair (MMR) genes MLH1, MSH2,
MSH6 and PMS2 cause autosomal dominantly inherited Lynch syndrome. Lynch syndrome …