Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We
explored how the microbiota was sensed by the immune system and the defining properties …

The cross-talk between the microbiota and the immune system plays a fundamental role in
the control of host physiology. However, the tissue-specific factors controlling this dialogue …

Background The skin harbors complex communities of resident microorganisms, yet little is
known of their physiological roles and the molecular mechanisms that mediate cutaneous …

Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

Intestinal commensal bacteria induce protective and regulatory responses that maintain host-
microbial mutualism. However, the contribution of tissue-resident commensals to immunity …

Skin wounds heal by coordinated induction of inflammation and tissue repair, but the
initiating events are poorly defined. Here we uncover a fundamental role of commensal skin …

The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …

The skin is colonized by a plethora of microbes that include commensals and potential
pathogens, but it is currently unknown how cutaneous host immune mechanisms influence …

INTRODUCTION Barrier tissues are constitutive targets of environmental stressors and are
home to a highly diverse microbiota. When the immune system encounters these …

Little is known about the impact of different microbial signals on skin barrier organ function
and the interdependency between resident microflora and pathogenic microorganisms. This …