Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase

T Azechi, D Kanehira, T Kobayashi, R Sudo… - … of atherosclerosis and …, 2013 - jstage.jst.go.jp
Aim: Vascular calcification, a major complication of chronic kidney disease (CKD), refers to
the mineralization of vascular smooth muscle cells (VSMCs), resulting from a phenotypic …

[HTML][HTML] Roles of histone acetylation modifiers and other epigenetic regulators in vascular calcification

DH Kwon, J Ryu, YK Kim, H Kook - International journal of molecular …, 2020 - mdpi.com
Vascular calcification (VC) is characterized by calcium deposition inside arteries and is
closely associated with the morbidity and mortality of atherosclerosis, chronic kidney …

5-aza-2ʹ-Deoxycytidine, a DNA methyltransferase inhibitor, facilitates the inorganic phosphorus-induced mineralization of vascular smooth muscle cells

T Azechi, F Sato, R Sudo, H Wachi - Journal of atherosclerosis and …, 2014 - jstage.jst.go.jp
Aim: Vascular calcification, an independent risk factor for cardiovascular disease in patients
with chronic kidney disease (CKD), refers to the mineralization of vascular smooth muscle …

[HTML][HTML] New aspects of vascular calcification: histone deacetylases and beyond

DH Kwon, YK Kim, H Kook - Journal of Korean Medical …, 2017 - synapse.koreamed.org
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically
deposited in the arteries. Previously, calcification was considered to be a passive process in …

Parathyroid hormone promotes osteoblastic differentiation of endothelial cells via the extracellular signal-regulated protein kinase 1/2 and nuclear factor-κB signaling …

ZY Cheng, T Ye, QY Ling, T Wu… - Experimental and …, 2018 - spandidos-publications.com
Vascular calcification (VC) occurs in patients with chronic kidney disease (CKD) and
contributes to cardiovascular dysfunction and mortality. Parathyroid hormone (PTH) is a …

Vascular smooth muscle cell differentiation to an osteogenic phenotype involves matrix metalloproteinase-2 modulation by homocysteine

T Liu, J Lin, T Ju, L Chu, L Zhang - Molecular and cellular biochemistry, 2015 - Springer
Arterial calcification is common in vascular diseases and involves conversion of vascular
smooth muscle cells (VSMCs) to an osteoblast phenotype. Clinical studies suggest that the …

Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress

FT Tang, SR Chen, XQ Wu, TQ Wang, JW Chen… - Calcified tissue …, 2006 - Springer
Hypercholesterolemia plays an important role in the initiation and progression of
atherosclerosis and has a positive correlation with cardiovascular disease. Calcification is a …

Calcification of aortic smooth muscle cells isolated from spontaneously hypertensive rats

K Kanemaru, K Seya, I Miki, S Motomura… - Journal of …, 2008 - jstage.jst.go.jp
Although hypertension and vascular calcification are well established as important risk
factors for several cardiovascular diseases, the relationship between them is unknown …

Salt‐inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification

A Abend, O Shkedi, M Fertouk, LH Caspi, I Kehat - EMBO reports, 2017 - embopress.org
A pathologic osteochondrogenic differentiation of vascular smooth muscle cells (VSMC s)
promotes arterial calcifications, a process associated with significant morbidity and mortality …

[HTML][HTML] Vascular calcification in chronic kidney disease: new developments in drug therapy

S Huybers, RJM Bindels - Kidney international, 2007 - Elsevier
Controlling the development of vascular calcification in chronic kidney disease is essential,
because it is associated with increased cardiovascular pathology. However, the precise …