Despite a dramatic increase in T-cell receptor (TCR) sequencing, few approaches
biologically parse the data in a fashion that both helps yield new information about immune …

T cells are integral components of the adaptive immune system, and their responses are
mediated by unique T-cell receptors (TCR) that recognize specific antigens from a variety of …

Recent advances in molecular and bioinformatic methods have greatly improved our ability
to study the formation of an adaptive immune response towards foreign pathogens, self …

Highlights•TCR repertoire analysis as a tool to advance cancer immunotherapy.•
Computational methods are used to understand TCR repertoire characteristics.•Both TCR …

T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …

Many experimental and bioinformatics approaches have been developed to characterize the
human T cell receptor (TCR) repertoire. However, the unknown functional relevance of TCR …

Motivation While growing numbers of T cell receptor (TCR) repertoires are being mapped by
high-throughput sequencing, existing methods do not allow for computationally connecting a …

We applied our computational algorithm TRUST4 to assemble immune receptor (T-cell
receptor/B-cell receptor) repertoires from approximately 12,000 RNA sequencing samples …

The T cell repertoire potentially presents complexity compatible, or greater than, that of the
human brain. T cell based immune response is involved with practically every part of human …

The T cell receptor repertoire provides a window into the cellular adaptive immune
response. In the context of cancer, determining the repertoire within a tumor can give …