Glymphatic dysfunction in migraine mice model

W Huang, Y Zhang, Y Zhou, J Zong, T Qiu, L Hu, S Pan… - Neuroscience, 2023 - Elsevier
The glymphatic system is important for waste removal in the central nervous system. It
removes soluble proteins and metabolic waste under the action of aquaporin-4 (AQP4) at …

Normal glymphatic system function in patients with migraine: a pilot study

DA Lee, HJ Lee, KM Park - … : The Journal of Head and Face …, 2022 - Wiley Online Library
Objective No studies have evaluated the glymphatic system function in patients with
migraine. In this pilot study, we evaluated and compared the alterations in the glymphatic …

Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space

X Zhang, W Wang, X Bai, X Zhang, Z Yuan… - The Journal of …, 2023 - Springer
Background Preliminary evidence suggests that several headache disorders may be
associated with glymphatic dysfunction. However, no studies have been conducted to …

Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …

The glymphatic system in migraine and other headaches

MG Vittorini, A Sahin, A Trojan, S Yusifli… - The Journal of …, 2024 - Springer
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic
solutes from the brain tissue. It is made of a network of perivascular spaces, filled in …

A systematic literature review on the role of glial cells in the pathomechanisms of migraine

S Zhang, J Azubuine, C Schmeer - Frontiers in molecular …, 2023 - frontiersin.org
Background The pathomechanisms underlying migraine are intricate and remain largely
unclear. Initially regarded as a neuronal disorder, migraine research primarily concentrated …

Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine

Y Zhou, M Pang, Y Ma, L Lu, J Zhang, P Wang… - Molecular …, 2024 - Springer
Migraine is a complex and multi-system dysfunction. The realization of its pathophysiology
and diagnosis is developing rapidly. Migraine has been linked to gastrointestinal disorders …

Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage

X Cao, H Xu, W Feng, D Su, M Xiao - Brain research bulletin, 2018 - Elsevier
The glymphatic pathway and meningeal lymphatic vessels are involved in clearance of
metabolic macromolecules from the brain. However, the functional interaction between the …

Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling

F Wei, J Song, C Zhang, J Lin, R Xue, LD Shan… - …, 2019 - Springer
Background The glymphatic system has recently been proposed to function as a brain-wide
macroscopic system for the clearance of potentially harmful molecules, such as amyloid beta …

Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus

GQ Wang, FX Wang, YN He… - Journal of neuroscience …, 2022 - Wiley Online Library
The glymphatic system is a recently discovered glial‐dependent macroscopic interstitial
waste clearance system that promotes the efficient elimination of soluble proteins and …