Gap junction intercellular communication is involved in ischemia–reperfusion (IR) injury of
organs. Connexins are proteins that are critical to the function of gap junctions. To clarify the …

Connexins are subunits of gap junction channels, which allow direct transfer of ions,
secondary messenger molecules, and other metabolites between contacting cells. Gap …

Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting.
Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; …

Objective: Liver fibrosis results from the perpetuation of the normal wound healing response
to several types of injury. Despite the wealth of knowledge regarding the involvement of …

Ischemic brain injury results in neuronal loss and associated neurologic deficits. Although
there is some evidence that intercellular communication via gap junctions can spread …

Primary hepatocyte cultures suffer from the progressive occurrence of dedifferentiation
followed by spontaneous apoptosis. This is associated with modifications in the expression …

Serial changes in expression of hepatic gap junction components, connexin32 and
connexin26 expressions during ischemia (60 min)-reperfusion injury of the liver were …

Gap junctions are thought to be necessary for proper tissue function. However, no clear
hepatic phenotype has been described in patients lacking connexin 32 (Cx32), the principal …

Background: Ischemia-reperfusion injury (IRI) is an injurious phenomenon that is the primary
determinant of liver dysfunction after surgery and transplantation. The present evidence …

Gap junctions (Gj) play an important role in the communication between cells of many
tissues. They are composed of channels that permit the passage of ions and low molecular …