Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The
cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a …

Plexins are cell-surface receptors for the semaphorin family of neuronal guidance cues.
Following semaphorin binding, the plexin cytoplasmic region initiates poorly understood …

Ten years ago nothing was known of the three-dimensional structure of members of the
semaphorin family of cell guidance cues, nor of their major receptors, the plexins. The …

Plexins are the receptors for semaphorins, a large family of axon guidance cues.
Accordingly, the role of plexins in the development of the nervous system was the first to be …

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for
regulating neuronal axon guidance. The intracellular region of plexins is essential for …

Semaphorins are a large family of secreted or cell-bound signals, known to guide axons in
developing nervous tissue. They are expressed in a variety of adult and embryonic tissues …

Ahallmark of semaphorin receptors is their interaction with multiple GTPases. Plexins, the
signal transducing component of semaphorin receptors, directly associate with several …

Plexins, comprising Plexin-A,-B,-C, and-D subfamilies, are receptors for semaphorins
governing cell adhesion, migration, and axon guidance. Among plexin subfamilies, Plexin …

Cell-cell signalling of semaphorin ligands through interaction with plexin receptors is
important for the homeostasis and morphogenesis of many tissues and is widely studied for …