As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Rho GTPases play central roles in numerous cellular processes, including cell motility, cell
polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …