Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder
afflicting millions of individuals across the world. While the availability of robust …
afflicting millions of individuals across the world. While the availability of robust …
New perspectives in glutamate and anxiety
CR Bermudo-Soriano, MM Perez-Rodriguez… - Pharmacology …, 2012 - Elsevier
Anxiety and stress-related disorders, namely posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …
Pharmacotherapy of PTSD: premises, principles, and priorities
LN Ravindran, MB Stein - Brain research, 2009 - Elsevier
Post-traumatic stress disorder (PTSD) is a prevalent anxiety disorder that results in multiple
disabling symptoms. Research into the underlying neurobiology has implicated …
disabling symptoms. Research into the underlying neurobiology has implicated …
The role of glutamate in anxiety and related disorders
BM Cortese, KL Phan - CNS spectrums, 2005 - cambridge.org
Anxiety, stress, and trauma-related disorders are a major public health concern in the United
States. Drugs that target the γ-aminobutyric acid or serotonergic system, such as …
States. Drugs that target the γ-aminobutyric acid or serotonergic system, such as …
Glutamate: The master neurotransmitter and its implications in chronic stress and mood disorders
MM Pal - Frontiers in Human Neuroscience, 2021 - frontiersin.org
This brief review article makes the argument that glutamate is deserving of its newfound
attention within the neuroscience literature and that many directions of important research …
attention within the neuroscience literature and that many directions of important research …
Considering future pharmacotherapy for PTSD
MJ Friedman, NC Bernardy - Neuroscience letters, 2017 - Elsevier
Posttraumatic stress disorder (PTSD) is a prevalent, disabling, and often chronic condition
that may develop following exposure to a traumatic event. Despite the immense social and …
that may develop following exposure to a traumatic event. Despite the immense social and …
[HTML][HTML] Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule
AY Onaolapo, OJ Onaolapo - World journal of psychiatry, 2021 - ncbi.nlm.nih.gov
The versatility of glutamate as the brain's foremost excitatory neurotransmitter and modulator
of neurotransmission and function is considered common knowledge. Years of research …
of neurotransmission and function is considered common knowledge. Years of research …
Glutamatergic dysfunction and glutamatergic compounds for major psychiatric disorders: evidence from clinical neuroimaging studies
Excessive glutamate release has been linked to stress and many neurodegenerative
diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or …
diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or …
Beyond monoamines: glutamatergic function in mood disorders
A Kugaya, G Sanacora - CNS spectrums, 2005 - cambridge.org
The monoamine theory has implicated abnormalities in serotonin and norepinephrine in the
pathophysiology of major depression and bipolar illness and contributed greatly to our …
pathophysiology of major depression and bipolar illness and contributed greatly to our …
Emerging evidence for the widespread role of glutamatergic dysfunction in neuropsychiatric diseases
T McGrath, R Baskerville, M Rogero, L Castell - Nutrients, 2022 - mdpi.com
The monoamine model of depression has long formed the basis of drug development but
fails to explain treatment resistance or associations with stress or inflammation. Recent …
fails to explain treatment resistance or associations with stress or inflammation. Recent …