Purpose: Microtubules are important cytoskeletal components involved in many cellular
events. Antimicrotubule agents including polymerizing agents (paclitaxel and docetaxel) and …

The Bcl2 family of proteins plays a significant role in regulation of apoptosis. In this study, the
microtubule-damaging drugs paclitaxel, vincristine, and vinblastine induced Bcl2 …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

We have investigated the ability of several drugs commonly used in the treatment of human
cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute …

Bcl-xL and Bcl-2 are phosphorylated in response to microtubule inhibitors, but the kinase (s)
responsible and the functional significance have remained unclear. In this study, we …

Over the past decade, significant progress has been made in our understanding of the
biology of microtubule (MT) assembly into the mitotic spindle during mitosis and the …

Specifically anti-microtubule agents such as taxol, vincristine, vinblastine and dolastatin can
trigger Bcl2 phosphorylation at G2-M phase of the cell cycle in malignant cells derived from …

Taxoids and other microtubule-damaging drugs are known to induce Bcl2 phosphorylation
at the G2-M phase of the cell cycle, with concomitant apoptosis in malignant cells derived …

Recent studies have shown that paclitaxel leads to activation of Raf-1 kinase and have
suggested that this activation is essential for bcl-2 phosphorylation and apoptosis. In the …

Abstract Raf-1 activation and Bcl-2 hyperphosphorylation following treatment with paclitaxel
(Taxol) or other microtubule-active drugs is associated with mitotic arrest. Here we show that …