Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment

PA Lapchak - Current neurology and neuroscience reports, 2002 - Springer
Hemorrhagic transformation (HT) is a frequent consequence of ischemic stroke that
becomes more prevalent after thrombolytic therapy. Despite concerns about safety …

Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence.

PD Lyden, JA Zivin - Cerebrovascular and brain metabolism …, 1993 - europepmc.org
Hemorrhagic infarction and cerebral hematoma are feared events that may follow cerebral
ischemia. Newly developed thrombolytic agents may be effective stroke therapy, but may …

Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors

BR Thanvi, S Treadwell… - Postgraduate Medical …, 2008 - academic.oup.com
Haemorrhagic transformation of cerebral infarction is a common and potentially serious
occurrence following acute ischaemic stroke. Though often a “natural” evolution, particularly …

Hemorrhagic transformation in focal cerebral ischemia: influence of time to artery reopening and tissue plasminogen activator

SC Fagan, JH Garcia - Pharmacotherapy: The Journal of …, 1999 - Wiley Online Library
We used an adaptation of a well‐established rat model of middle cerebral artery occlusion
(MCAO) that is both minimally invasive and reproducible to determine the effects of time to …

Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study

V Larrue, R von Kummer, G del Zoppo, E Bluhmki - Stroke, 1997 - Am Heart Assoc
Background and Purpose Recent studies suggest that thrombolytic therapy may be of
benefit to patients with acute ischemic stroke. However, the treatment also carries a …

Hemorrhagic infarcts

T Moulin, T Crépin-Leblond, JL Chopard… - European …, 1994 - karger.com
A review of hemorrhagic transformation after brain ischemia is presented. The pathological,
clinical and radiological aspects are discussed with respect to recent studies. The different …

Usefulness of postischemic thrombolysis with or without neuroprotection in a focal embolic model of cerebral ischemia

Y Yang, Q Li, H Miyashita, W Howlett, M Siddiqui… - Journal of …, 2000 - thejns.org
Object. Recent studies have shown that the use of thrombolysis in the setting of acute stroke
is associated with an increased risk of cerebral hemorrhage. The time of onset of symptoms …

Hemorrhagic transformation: the spectrum of ischemia-related brain hemorrhage

PA Teal, MS Pessin - Neurosurgery Clinics of North America, 1992 - Elsevier
Hemorrhagic transformation of ischemic cerebral injury occurs commonly in embolic strokes.
The incidence, timing, and clinical consequences of hemorrhagic transformation are …

Hemorrhagic transformation after ischemic stroke in animals and humans

GC Jickling, DZ Liu, B Stamova… - Journal of Cerebral …, 2014 - journals.sagepub.com
Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …

Hemorrhagic transformation after ischemic stroke: mechanisms and management

JM Hong, DS Kim, M Kim - Frontiers in Neurology, 2021 - frontiersin.org
Symptomatic hemorrhagic transformation (HT) is one of the complications most likely to lead
to death in patients with acute ischemic stroke. HT after acute ischemic stroke is diagnosed …